天师栗化学成分的研究

STUDIES ON THE CHEMICAL CONSTITUENTS FROM THE SEEDS OF AESCULUS WILSONII REHD.

摘要: 目的：从中药天师栗(Aesculus wilsonii Rehd.)的干燥成熟果实中寻找新的有效成分。方法：利用各种色谱技术进行纯化，根据理化性质和各种光谱技术(IR,EIMS,FABMS,¹HNMR,¹³CNMR,¹H-¹H COSY,¹³C-¹H COSY)进行结构鉴定。结果：从天师栗的95%乙醇浸膏的乙酸乙酯和己烷部分共分得5个化合物。分别鉴定为：天师酸(1),富马酸(2)，乙酰谷氨酸(3),β-谷甾醇-3-O-葡糖苷(4)，β-谷甾醇(5)。结论：化合物1为新化合物，2和3是从本科植物首次分得。

Abstract: AIM: To look for new active constituents from the seeds of Aesculus wilsonii Rehd., a Chinese medicine. METHODS: Various column chromatographic techniques were employed for the isolation and purification of the ingredients. The structures were elucidated on the basis of spectral evidences and chemical reactions. RESULTS: 5 compounds were obtained and identified as tianshic acid (1), fumaric acid (2), N-acetyl glutaminic acid (3), β-sitosterol 3-O-gluceroside (4) and β-sitosterol (5). CONCLUSION: Tianshic acid is a new compound, and fumaric acid (2) and N-acetyl glutaminic (3) are known compounds unreported previously from this kind of plant.