雷公藤三萜成分

THE TRITERPENOIDS OF TRIPTERYGIUM WILFORDII

摘要: 目的：研究雷公藤(Tripterygium wilfordii Hook.f)根心部分化学成分。方法：采用硅胶柱色谱法进行分离,运用现代波谱技术分析鉴定了8个三萜。结果：经光谱鉴定化合物为：雷公藤内酯甲(wilforlide A 1),雷公藤内酯乙(wilforlide B 2)，3-epikatonic acid (3)，cangoronine (4)，regelin (5)，salaspermic acid (6)，3-hydroxy-2-oxo-3-fridelen-20α-carboxylic acid (7)以及新化合物3β-hydroxy-D∶B-friedoolean-5∶6 epoxy-29-oic acid (8)，后者命名为triptotin C。结论：化合物8为新化合物。

Abstract: AIM: To study the active principles of Tripterygium wilfordii Hook f. METHODS: Various column chromatographies with silica gel were employed for the isolation and purification of the ingredients. Their structures were elucidated by spectral analysis. RESULTS: Eight triterpenoids were obtained and were identified as wilforlide A (1), wilforlide B (2), 3-epikatonic acid (3), cangoronine (4), regelin (5), salaspermic acid (6), 3-hydroxy-2-oxo-3-fridelen-20α-carboxylic acid (7) and a new compound triptotin C (3β-hydroxy-D∶B-friedoolean-5∶6 epoxy-29-oic acid) (8). CONCLUSION: Compound (8) was a new compound.