21-氯代达哪唑及其C<sub>6</sub>-脱氢物的合成

施菊芳, 廖清江, 徐芳. 21-氯代达哪唑及其C₆-脱氢物的合成J. 药学学报, 1988, 23(11): 860-862.

引用本文:

施菊芳, 廖清江, 徐芳. 21-氯代达哪唑及其C₆-脱氢物的合成J. 药学学报, 1988, 23(11): 860-862.

JF Shi, QJ Liao , F Xu, . SYNTHESIS OF 21-CHLORODANAZOL AND ITS △⁶-ANALOGUEJ. Acta Pharmaceutica Sinica, 1988, 23(11): 860-862.

Citation:

JF Shi, QJ Liao , F Xu, . SYNTHESIS OF 21-CHLORODANAZOL AND ITS △⁶-ANALOGUEJ. Acta Pharmaceutica Sinica, 1988, 23(11): 860-862.

21-氯代达哪唑及其C₆-脱氢物的合成

Abstract: Synthesis was undertaken of 21-chloro-danazol (Ⅳa) and 21-chloro-6-dehydro-danazol (Ⅳb). The binding ability of these compounds to progesterone receptor were examined and were found to be less active than danazol.Compound (Ⅳa) showed significant activity for eary pregnancy termination effect in Sprague-Dawley rats.

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