Abstract: A general-purpose PVC membrane electrode with inner graphite contact has been proposed for analysis of some organic drugs. The PVC membrane was prepared from hexadecyltrioctylammonium iodide with dibutylphthalate as the solvent mediator. The electrode can be activated by conditioning with the solution of the corresponding drug to be determined. The potentiometric response characteristics of the electrode with respect to thiopental, phenobarbital, amobarbital, phenytoin, ethacrynic acid and salicylate were studied and the optimum pH and concentration range of the electrode for different organic drugs were found. The potentiometric determination of the aforementioned drugs gave satisfactory recovery.