毛峰, 王超, 程铁明, 蔡孟深, 张春英, 陶其敏. 多肽研究——Ⅸ.乙型肝炎病毒表面抗原(HBsAg)Pre-S区域肽段的合成和抗原特异性测定J. 药学学报, 1992, 27(6): 428-433.
引用本文: 毛峰, 王超, 程铁明, 蔡孟深, 张春英, 陶其敏. 多肽研究——Ⅸ.乙型肝炎病毒表面抗原(HBsAg)Pre-S区域肽段的合成和抗原特异性测定J. 药学学报, 1992, 27(6): 428-433.
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F Mao, C Wang, TM Cheng, MS Cai, CY Zhang, QM Tao. STUDIES ON POLYPEPTIDES Ⅸ.SYNTHESIS AND ANTIGEN SPECIFICITY OF PRE-S REGION FRAGMENTS OF HEPATITIS B SURFACE ANTIGENJ. Acta Pharmaceutica Sinica, 1992, 27(6): 428-433.
Citation: F Mao, C Wang, TM Cheng, MS Cai, CY Zhang, QM Tao. STUDIES ON POLYPEPTIDES Ⅸ.SYNTHESIS AND ANTIGEN SPECIFICITY OF PRE-S REGION FRAGMENTS OF HEPATITIS B SURFACE ANTIGENJ. Acta Pharmaceutica Sinica, 1992, 27(6): 428-433.
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多肽研究——Ⅸ.乙型肝炎病毒表面抗原(HBsAg)Pre-S区域肽段的合成和抗原特异性测定

STUDIES ON POLYPEPTIDES Ⅸ.SYNTHESIS AND ANTIGEN SPECIFICITY OF PRE-S REGION FRAGMENTS OF HEPATITIS B SURFACE ANTIGEN

    摘要
  • 摘要: 采用溶液法和固相法,合成了HBsAg Pre-S蛋白区域七个六肽片段。将其与载体蛋白结合。用多克隆抗HBsAg和单克隆抗“α”测定了肽—蛋白结合物的抗原特异性,结果表明P1和P5有较高的抗原特异性。

     

    Abstract: Seven peptide fragments of HBsAg Pre-S region have been synthesizedby liquid phase and solid phase methods. All peptide fragments were linked to protein car-rier by carbodiimide and glutaraldehyde methods. The antigen specificity of thepeptide-protein conjugates was assayed by anti-HBsAg polyclonal antibodies and anti-"a" monoconal antibody. P1 and P5 were found to have higher antigen specificity.

     

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