张丹参, 薛贵平, 张力, 张士善. 脑室注射N-甲基-D-门冬氨酸对小鼠学习记忆的影响J. 药学学报, 1993, 28(5): 321-325.
引用本文: 张丹参, 薛贵平, 张力, 张士善. 脑室注射N-甲基-D-门冬氨酸对小鼠学习记忆的影响J. 药学学报, 1993, 28(5): 321-325.
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DS Zhang, GP Xue, L Zhang , SS Zhang, . EFFECT OF INTRACEREBROVENTRICULAR INJECTION OF N-METHYL-D-ASPARTATE ON LEARNING AND MEMORY IN MICEJ. Acta Pharmaceutica Sinica, 1993, 28(5): 321-325.
Citation: DS Zhang, GP Xue, L Zhang , SS Zhang, . EFFECT OF INTRACEREBROVENTRICULAR INJECTION OF N-METHYL-D-ASPARTATE ON LEARNING AND MEMORY IN MICEJ. Acta Pharmaceutica Sinica, 1993, 28(5): 321-325.
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脑室注射N-甲基-D-门冬氨酸对小鼠学习记忆的影响

EFFECT OF INTRACEREBROVENTRICULAR INJECTION OF N-METHYL-D-ASPARTATE ON LEARNING AND MEMORY IN MICE

    摘要
  • 摘要: 采用一次性被动回避性条件反射方法,给小鼠icv N-甲基-D-门冬氨酸(NMDA)10,1和0.1 ng。结果表明:对正常小鼠,在跳台法中NMDA 10 ng能明显增强记忆巩固过程,在避暗法中NMDA 1 ng能显著增强记忆再现过程;在两种方法中,NMDA 1 ng均能显著改善乙醇及亚硝酸钠所致记忆障碍;而NMDA对记忆获得过程无影响。进一步研究表明,NMDA改善记忆的作用可被其受体特异性拮抗剂AP5所拮抗。结合以前报道和电生理研究结果提示,谷氨酸受体NMDA亚型在记忆过程中起着重要的作用,脑室给药作用的环节主要是影响记忆巩固和再现过程。

     

    Abstract: In one trial passive avoidance response in mice, the effect of N-methyl-Daspartate (NMDA) on acquisition, consolidation and retrieval of memory were observed after icy administration of 10 ng, 1 ng or 0. 1 ng/mouse. The results showed that NMDA 10 ng/mouse could promote the consolidation of memory in step-down test and 1 ng/mouse could promote the retrieval of memory in step-through test. NMDA 1 ng/mouse significantly improved the retrieval impairment induced by 30% alcohol and the consolidation impairment induced by NaNO2 in step-down and stepthrough tests. The effect of NMDA on memory was antagonized by NMDA receptor antagonist, AP5. These results provide direct evidence for the action of NMDA subtype of glutamate receptor on memory.

     

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