孟伟, 金文藻. 新抗生素波拉霉素 A 和 B 的结构测定J. 药学学报, 1997, 32(5): 352-356.
引用本文: 孟伟, 金文藻. 新抗生素波拉霉素 A 和 B 的结构测定J. 药学学报, 1997, 32(5): 352-356.
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W Meng, WZ Jin. STRUCTURE DETERMINATION OF NEW ANTIFUNGAL ANTIBIOTICS, POLARAMYCINS A AND BJ. Acta Pharmaceutica Sinica, 1997, 32(5): 352-356.
Citation: W Meng, WZ Jin. STRUCTURE DETERMINATION OF NEW ANTIFUNGAL ANTIBIOTICS, POLARAMYCINS A AND BJ. Acta Pharmaceutica Sinica, 1997, 32(5): 352-356.
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新抗生素波拉霉素 A 和 B 的结构测定

STRUCTURE DETERMINATION OF NEW ANTIFUNGAL ANTIBIOTICS, POLARAMYCINS A AND B

    摘要
  • 摘要: 从一株吸水链霉菌（streptomyces hygroscopicus ）LP-93 的培养物中分离到新抗真菌抗生素—波拉霉素Ａ和Ｂ。它们属于多羟基大环内酯抗生素。基于光谱数据（ＵＶ，ＩＲ，1HNMR，13ＣＮＭＲ，ＤＥＰＴ，1H1ＨＣＯＳＹ，ＨＥＴＣＯＲ，ＨＭＢＣ）波拉霉素Ａ和Ｂ的结构阐明如图１，其中波拉霉素Ａ，Ｒ＝Ｈ；波拉霉素Ｂ，Ｒ＝ＣＨ3。

     

    Abstract: Antifungal antibiotics, polaramycins A and B have been isolated from the culture of Streptomyces hygroscopicus LP-93. Polaramycins A and B are 36 membered polyol macrolide antbiotics containing hemiacetal monoester of malonic acid and guanidyl groups. Based on spectral evidence including UV, IR, FABMS, 1HNMR, 13CNMR, DEPT, 1H-1H COSY, HETCOR, HMBC, the structure of polaramycins A and B have been assigned as shown in Fig 1 (A, R=H; B, R=CH3).

     

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