In this work, polyelectrolyte microcapsules containing gold nanoparticles were prepared via layer by layer assembly.  Gold nanoparticles and poly (allyamine hydrochloride) (PAH) were coated on the CaCO₃ microparticles.  And then EDTA was used to remove the CaCO₃ core.  Scanning electron microscopy (SEM) was used to characterize the surface of microcapsules.  SEM images indicate that the microcapsules and the polyelectrolyte multilayer were deposited on the surface of CaCO₃ microparticles.  FITC-bovine serum albumin (FITC-BSA, 2 mg) was incorporated in the CaCO₃ microparticles by co-precipitation.  Fluorescence microscopy was used to observe the fluorescence intensity of microcapsules.  The encapsulation efficiency was (34.31 ± 2.44) %.  The drug loading was (43.75 ± 3.12) mg·g⁻¹.