游育红, 林志彬. 灵芝多糖肽的抗氧化作用J. 药学学报, 2003, 38(2): 85-88.
引用本文: 游育红, 林志彬. 灵芝多糖肽的抗氧化作用J. 药学学报, 2003, 38(2): 85-88.
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YOU Yu-hong, LIN Zhi-bin. Antioxidant effect of Ganoderma polysaccharide peptideJ. Acta Pharmaceutica Sinica, 2003, 38(2): 85-88.
Citation: YOU Yu-hong, LIN Zhi-bin. Antioxidant effect of Ganoderma polysaccharide peptideJ. Acta Pharmaceutica Sinica, 2003, 38(2): 85-88.
shu

灵芝多糖肽的抗氧化作用

Antioxidant effect of Ganoderma polysaccharide peptide

    摘要
  • 摘要: 目的 研究灵芝多糖肽(GLPP)的抗氧化作用及其机制。 方法 Cu2+诱导人血清低密度脂蛋白(LDL)氧化及iv四氧嘧啶(75 mg·kg-1)引发小鼠氧自由基损伤。结果GLPP使LDL氧化修饰减少,氧化产物REM降低。GLPP 50,100,200和400 mg·kg-1 ip 20 d,使血清和心肌匀浆的丙二醛(MDA)水平下降, 谷胱甘肽过氧化物酶(GSHpx)升高,超氧化物歧化酶(SOD)减少,过氧化氢酶(CAT)不变。结论GLPP具有体内外抗氧化作用,其抗氧化作用与清除氧自由基或提高GSHpx水平有关。

     

    Abstract: AimTo study the antioxidant effect of Ganoderma polysaccharide peptide (GLPP) and its mechanism. MethodsCopper was used as oxidant to induce low lipoprotein (LDL) oxidative modification, and alloxan was given iv to induce reactive oxygen species (ROS) injury in mice. ResultsGLPP decreased oxidation of LDL and the relative electrophoretic mobility (REM) of oxidative product of LDL. After GLPP was given ip for 20 days, the concentration of malondialdehyde(MDA) in serum and heart of mice was decreased. The GSHpx enzyme activity was increased, while the SOD level was decreased. The catalase(CAT) levels were not significantly changed by GLPP. ConclusionGLPP showed antioxidant effect by scavenging ROS or enhancing the enzyme activity of GSHpx in vivo and in vitro.

     

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