消旋15(<i>R</i>)-15-甲基PGE<sub>2</sub>甲酯的合成

金碧燕, 吴元鎏, 张守仁, 徐瑞明. 消旋15(R)-15-甲基PGE₂甲酯的合成J. 药学学报, 1996, 31(10): 795-797.

引用本文:

金碧燕, 吴元鎏, 张守仁, 徐瑞明. 消旋15(R)-15-甲基PGE₂甲酯的合成J. 药学学报, 1996, 31(10): 795-797.

BY Jin, YL Wu, SR Zhang , RM xu, . SYNTHESIS OF d,l-15(R)-15-METHYL-PGE₂ METHYL ESTERJ. Acta Pharmaceutica Sinica, 1996, 31(10): 795-797.

Citation:

BY Jin, YL Wu, SR Zhang , RM xu, . SYNTHESIS OF d,l-15(R)-15-METHYL-PGE₂ METHYL ESTERJ. Acta Pharmaceutica Sinica, 1996, 31(10): 795-797.

消旋15(R)-15-甲基PGE₂甲酯的合成

Abstract: d,l-15(R)-15-Methyl-PGF_2α methyl ester 11-trimethylsilyl ether(II)wasprepared from selective monosilylation of d,l-15(R)-15-methyl-PGF_2αmethyl ester(I) withtrimethylsilyldiethylamine in acetone. Oxidation of(II ) with Collin's reagent gave d,l-15(R)-15-methyl-PGE₂ methyl ester 11-trimethylsilyl ether(III)which,without purification,was converted to d,l-15(R)-15-methyl-PGE₂ methyl ester(IV)under mild acidic conditions.

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