洪山海, 马广恩. 石蒜科生物碱的研究 Ⅲ.紫花石蒜和其他两种石蒜中的生物碱及新生物碱紫花石蒜碱J. 药学学报, 1964, 11(1): 1-1.
引用本文: 洪山海, 马广恩. 石蒜科生物碱的研究 Ⅲ.紫花石蒜和其他两种石蒜中的生物碱及新生物碱紫花石蒜碱J. 药学学报, 1964, 11(1): 1-1.
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HUNG SHAN-HAI MA GUANG-EN, . STUDIES ON THE ALKALOIDS OF AMARYLLIDACEAE——Ⅲ.THE ALKALOIDS OF LYCORIS SQUAMIGERA MAXIM.AND OTHER TWO LYCORIS SPECIES,AND A NEW ALKALOID,SQUAMIGERINEJ. Acta Pharmaceutica Sinica, 1964, 11(1): 1-1.
Citation: HUNG SHAN-HAI MA GUANG-EN, . STUDIES ON THE ALKALOIDS OF AMARYLLIDACEAE——Ⅲ.THE ALKALOIDS OF LYCORIS SQUAMIGERA MAXIM.AND OTHER TWO LYCORIS SPECIES,AND A NEW ALKALOID,SQUAMIGERINEJ. Acta Pharmaceutica Sinica, 1964, 11(1): 1-1.
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石蒜科生物碱的研究 Ⅲ.紫花石蒜和其他两种石蒜中的生物碱及新生物碱紫花石蒜碱

STUDIES ON THE ALKALOIDS OF AMARYLLIDACEAE——Ⅲ.THE ALKALOIDS OF LYCORIS SQUAMIGERA MAXIM.AND OTHER TWO LYCORIS SPECIES,AND A NEW ALKALOID,SQUAMIGERINE

    摘要
  • 摘要: 从紫花石蒜Lycoris squamigera Maxim.中分得19种结晶性生物碱,其中12种生物碱分别证明为lycorine,pseudolycorine,lycorenine,homolycorine,tazettine,norpluviine,galanthamine,epigalanthamine,vittatine,pluviine,lycoramine,hippeastrine;分得一种新生物碱,命名为紫花石蒜碱squamigerine. 紫花石蒜碱,C18H21O5N,熔点260℃,αD34+165°(氯仿),含有次甲二氧基、氯甲基、甲氧基、羟基和双键各1个。紫花石蒜碱的分子式及官能团均与tazettine相同;熔点,αD及Rf值不同。因而推想紫花石蒜碱可能为tazettine的异构体。我们进行了两者的紫外及红外吸收光就业谱的比较,发现它们彼此非常相似。因为紫花石蒜碱又与epitazettine 显然不同,所以推定它可能为B/D或C/D环系统结合不同于tazettine 的立体异构体。从红花石蒜L.radiata Herb.中分得7种已知生物碱:lycorine,homolycorine,tazettine,galanthamine,lycoramine,Iycorenine和pseudolycorine.从1种栽培的黄花石蒜中也分得上述7种生物碱。

     

    Abstract: Nineteen crystalline alkaloids have been isolated from the bulbs of Lycoris squamigera Maxim. Twelve of them have been proved to be identical with lycorine, pseudolycorine, lycorenine, homolycorine, tazettine, norpluviine, galanthamine, epigalanthamine, vittatine, pluviine, lycoramine, hippeastrine, respectively. One of them has been proved to be a new alkaloid, and named squamigerine. The new alkaloid, squamigerine, C18H21O5N, m. p. 260℃, αD34 165° (CHCl3), contained one methylenedioxy, methoxy, N-methyl, hydroxy group and one double bond. Its molecular formula and functional groups were identical with those of tazettine, but its m. p., αD and Rf were different from those of the latter. To confirm if squamigerine is the stereoisomer of tazettine, we compared the ultraviolet and infrared absorbtion spectra of them, and found that they resembled each other very closely. Because squamigerine is also apparently not identical to epitazettine, it was deduced to be the stereoisomer of tazettine, in which the B/D or C/D ring system was different from that of tazettine. Besides, seven crystalline alkaloids have been isolated from L. radiata Herb., and proved to be identical with Iycorine, pseudolycorine, homolycorine, tazettine, galanthamine, lycoramine and lycorenine respectively. The same seven alkaloids have also been isolated from L. aurea Herb.

     

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