段廷漢, 雷兴翰. 6-氨基青霉烷酸衍生物的研究Ⅰ.6-(取代丙烯酰氨)青霉烷酸的合成J. 药学学报, 1965, 12(8): 516-522.
引用本文: 段廷漢, 雷兴翰. 6-氨基青霉烷酸衍生物的研究Ⅰ.6-(取代丙烯酰氨)青霉烷酸的合成J. 药学学报, 1965, 12(8): 516-522.
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DWAN T'ING-HAN AND LEI HSING-HAN, . DERIVATIVES OF 6-AMINOPENICILLANIC ACID Ⅰ. SYNTHESIS OF 6-(SUBSTITUTED ACRYLAMIDO) PENICILLANIC ACIDJ. Acta Pharmaceutica Sinica, 1965, 12(8): 516-522.
Citation: DWAN T'ING-HAN AND LEI HSING-HAN, . DERIVATIVES OF 6-AMINOPENICILLANIC ACID Ⅰ. SYNTHESIS OF 6-(SUBSTITUTED ACRYLAMIDO) PENICILLANIC ACIDJ. Acta Pharmaceutica Sinica, 1965, 12(8): 516-522.
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6-氨基青霉烷酸衍生物的研究Ⅰ.6-(取代丙烯酰氨)青霉烷酸的合成

DERIVATIVES OF 6-AMINOPENICILLANIC ACID Ⅰ. SYNTHESIS OF 6-(SUBSTITUTED ACRYLAMIDO) PENICILLANIC ACID

    摘要
  • 摘要: 本文报导了22个6-(取代丙烯酰氨)青霉烷酸化合物的合成.这类化合物系以相应的取代丙烯酸,通过混合酸酐或酰氯,在微碱性、低温下,与6APA进行缩合;再以N-乙基六氢吡啶或N,N′-二苄基乙二胺成盐纯化精制.它们的抗菌作用正在筛选中.

     

    Abstract: Twenty-two new derivatives of 6-aminopenicillanic acid have been prepared either by the mixed carboxylic-carbonic anhydride or by the usual acyl chloride method. They were isolated and purified either as their N-ethylpiperidine or as their N, N'-dibenzyl- ethylenediamine salts. Biological evaluations of these derivatives are in progress.

     

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