王广树, 杨晓虹, 徐景达. 东北刺人参叶中四种新三萜皂苷的分离与结构鉴定J. 药学学报, 2004, 39(5): 354-358.
引用本文: 王广树, 杨晓虹, 徐景达. 东北刺人参叶中四种新三萜皂苷的分离与结构鉴定J. 药学学报, 2004, 39(5): 354-358.
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WANG Guang-shu, YANG Xiao-hong, XU Jing-da. Structures of four new triterpenoid saponins from the leaves of Oplopanax elatus NakaiStructures of four new triterpenoid saponins from the leaves of Oplopanax elatus NakaiJ. Acta Pharmaceutica Sinica, 2004, 39(5): 354-358.
Citation: WANG Guang-shu, YANG Xiao-hong, XU Jing-da. Structures of four new triterpenoid saponins from the leaves of Oplopanax elatus NakaiStructures of four new triterpenoid saponins from the leaves of Oplopanax elatus NakaiJ. Acta Pharmaceutica Sinica, 2004, 39(5): 354-358.
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东北刺人参叶中四种新三萜皂苷的分离与结构鉴定

Structures of four new triterpenoid saponins from the leaves of Oplopanax elatus NakaiStructures of four new triterpenoid saponins from the leaves of Oplopanax elatus Nakai

    摘要
  • 摘要: 目的研究东北刺人参的三萜皂苷化学成分。方法采用大孔树脂、硅胶、ODS柱色谱分离纯化，经理化常数、光谱学方法鉴定结构。结果分离得到了4个新三萜皂苷，其结构分别鉴定为3-O-β-D-吡喃葡糖基3β，23-二羟基羽扇豆-20(29)-烯-28-酸-28-O-α-L-吡喃鼠李糖基(1→4)-β-D-吡喃葡糖基(1→6)-β-D-吡喃葡糖苷(1);3-O-β-D-吡喃葡糖基常春藤皂苷元-28-O-α-L-吡喃鼠李糖基(1→4)-β-D-吡喃葡糖基(1→6)-β-D-吡喃葡糖苷(2);3-O-β-D-吡喃葡糖基3β-羟基齐墩果-9(11)，12-二烯-28-酸-28-O-α-L-吡喃鼠李糖基(1→4)-β-D-吡喃葡糖基(1→6)-β-D-吡喃葡糖苷(3);3α-羟基齐墩果-12-烯-23，28-二酸-28-O-α-L-吡喃鼠李糖基(1→4)-β-D-吡喃葡糖基(1→6)-β-D-吡喃葡糖苷(4)。结论化合物1～4均为新三萜皂苷，首次从东北刺人参叶中分得。

     

    Abstract: AimIsolation and structural elucidation of the triterpenoid saponins of Oplopanax elatus Nakai. MethodsSolvent extraction and column chromatography were used to isolate the triterpenoid saponins, physico-chemical constants and spectroscopic analysis were employed for structural elucidation. ResultsFour new triterpenoid saponins named cirenshenoside S (1), cirenshenoside T (2), cirenshenoside U (3) and cirenshenoside V (4) were isolated, and their structures were elucidated to be 3-O-β-D-glucopyranosyl 3β,23-dihydroxylup-20(29)-en-28-oic acid 28-O-α-L-rhamnopyranosyl(1→4)-β-D-glucopyranosyl(1→6)-β-D-glucopyranoside (1), 3-O-β-D-glucopyranosyl hederagenin 28-O-α-L-rhamnopyranosyl(1→4)-β-D-glucopyranosyl(1→6)-β-D-glucopyranoside (2), 3-O-β-D-glucopyranosyl 3β-hydroxyolean-9(11),12-dien-28-oic acid 28-O-α-L-rhamnopyranosyl(1→4)-β-D-glucopyranosyl(1→6)-β-D-glucopyranoside (3) and 3α-hydroxyolean-12-dien-23,28-dioic acid 28-O-α-L-rhamnopyranosyl(1→4)-β-D-glucopyranosyl(1→6)-β-D-glucopyranoside (4), respectively. ConclusionCompounds 1-4 are new triterpenoid saponins and isolated from the leaves of Oplopanax elatus Nakai for the first time.

     

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