Abstract: AimTo investigate the preparation, shape and ultrasound triggered release characteristics of gelatin nanogel modified with fluoride anion. MethodsAdriamycin gelatin nanogel modified with fluoride anion (ADM-FMNG) was prepared by co-precipitation with fluoride anion. The content and encapsulation rate of adriamycin were measured by HPLC method. The size and shape of ADM-FMNG were determined by electron microscope. The size and distribution of ADM-FDNG before and after sonication were measured by laser size analysis device. ResultsThe average diameter of ADM-FMNG was (46±12) nm. Adriamycin encapsulated rate and loading were 87.2% and 0.091 g·L^-1, respectively. 48.5% of adriamycin was released within 50 h while in vitro at 37 ℃. Under the action of ultrasound that has the frequency of 20 kHz, 0.4 W·cm^-2 of power density and 7-8 min duration, 51.5% of adriamycin in ADM-FMNG was released that was significantly higher than control group, the size of ADM-FMNG was changed from (46±12) nm to (1 212±35) nm and restored after ultrasound stopped for 3-4 min. ConclusionADM-FDNG system has the sensitive ultrasound triggered release characteristics.