Abstract: Weight variations of 28 lots of various native pills "Shui-fan-wan" (pills aggregated with water or diluted honey excipient), manufactured in bulk with various powdered crude drugs by different methods, were investigated. The results obtained were as follows: (1)It has been found that the distribution of pill weights showed, in general, a normal distribution. (2)The sample correlation coefficient between the logarithms of mean pill weight and coefficients of variation, was calculated as -0.841. (3)The sample regression equation of ■ on X has been found to be: ■= 30.50 - 10.04 X where■y is the estimated deviation of coefficient of variation and X is the logarithm of mean pill weight.