N-(2-甲氧羰基苯氧/硫乙酰基)-N-取代甘氨酸的合成

江云; 龚康孙; 蔡纯一; 周群; 虞文

江云, 龚康孙, 蔡纯一, 周群, 虞文. N-(2-甲氧羰基苯氧/硫乙酰基)-N-取代甘氨酸的合成J. 药学学报, 1995, 30(2): 150-156.

引用本文:

江云, 龚康孙, 蔡纯一, 周群, 虞文. N-(2-甲氧羰基苯氧/硫乙酰基)-N-取代甘氨酸的合成J. 药学学报, 1995, 30(2): 150-156.

Y Jiang, KS Gong, GY Cai, Q Zhou , W Yu, . SYNTHESIS OF N-(2-CARBOMETHOXYPHENYLOXY/THIO A CETYL)-N-SUBSTITUTED GLYCINESJ. Acta Pharmaceutica Sinica, 1995, 30(2): 150-156.

Citation:

Y Jiang, KS Gong, GY Cai, Q Zhou , W Yu, . SYNTHESIS OF N-(2-CARBOMETHOXYPHENYLOXY/THIO A CETYL)-N-SUBSTITUTED GLYCINESJ. Acta Pharmaceutica Sinica, 1995, 30(2): 150-156.

N-(2-甲氧羰基苯氧/硫乙酰基)-N-取代甘氨酸的合成

SYNTHESIS OF N-(2-CARBOMETHOXYPHENYLOXY/THIO A CETYL)-N-SUBSTITUTED GLYCINES

摘要

Abstract: Thirteen N-(2-carbomethoxyphenyl oxy/thio acetyl)-N-substituted glycines (VI _1-7 and XI_1-6) expected to have inhibitory activity on angiotensin-converting enzyme were synthesized.All of the title compounds and thirteen corresponding t-butyl esters(V_1-7 and X_1-6) were not found in literature.In preliminary test,the inhibitory activity activity of compound XI₅ on ACE in vitro was 70% that of captoprill.

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