杨玉社, 嵇汝运, 胡增建, 陈凯先. 左旋氧氟沙星不对称合成新方法研究J. 药学学报, 1998, 33(11): 828-831.
引用本文: 杨玉社, 嵇汝运, 胡增建, 陈凯先. 左旋氧氟沙星不对称合成新方法研究J. 药学学报, 1998, 33(11): 828-831.
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Yang Yushe, Ji Ruyun, Hu Zengjian , Chen Kaixian, . A NEW PRACTICAL ROUTE TO STEREOSPECIFIC SYNTHESIS OF (S)-(-)-OFLOXACINJ. Acta Pharmaceutica Sinica, 1998, 33(11): 828-831.
Citation: Yang Yushe, Ji Ruyun, Hu Zengjian , Chen Kaixian, . A NEW PRACTICAL ROUTE TO STEREOSPECIFIC SYNTHESIS OF (S)-(-)-OFLOXACINJ. Acta Pharmaceutica Sinica, 1998, 33(11): 828-831.
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左旋氧氟沙星不对称合成新方法研究

A NEW PRACTICAL ROUTE TO STEREOSPECIFIC SYNTHESIS OF (S)-(-)-OFLOXACIN

    摘要
  • 摘要: 以(S)-乳酸乙酯为手性起始原料,经10步反应合成了抗菌药物左旋氧氟沙星。该方法起始原料丰富易得,反应条件温和,收率好,产物光学纯度高。

     

    Abstract: (S)-(-)-ofloxacin is one of the best fluoroquinolone agents in current clinical use. A new facile practical route with good yield and high optical purity to stereospecific synthesis of (S)-(-)-ofloxacin was described.

     

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