吴久鸿, 廖时萱, 毛士龙, 易杨华, 竹谷孝一, 苏中武, 蓝传青. 毛叶假鹰爪根化学成分的研究J. 药学学报, 1999, 34(9): 682-685.
引用本文: 吴久鸿, 廖时萱, 毛士龙, 易杨华, 竹谷孝一, 苏中武, 蓝传青. 毛叶假鹰爪根化学成分的研究J. 药学学报, 1999, 34(9): 682-685.
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Wu Jiuhong, Liao Shixuan, Mao Shilong, Yi Yanghua Takeya K, Su Zhongwu , Lan Chuanqing (Lan CQ), . STUDIES ON THE CHEMICAL CONSTITUENTS FROM DESMOS DUMOSUS (ROXB.) SAFFJ. Acta Pharmaceutica Sinica, 1999, 34(9): 682-685.
Citation: Wu Jiuhong, Liao Shixuan, Mao Shilong, Yi Yanghua Takeya K, Su Zhongwu , Lan Chuanqing (Lan CQ), . STUDIES ON THE CHEMICAL CONSTITUENTS FROM DESMOS DUMOSUS (ROXB.) SAFFJ. Acta Pharmaceutica Sinica, 1999, 34(9): 682-685.
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毛叶假鹰爪根化学成分的研究

STUDIES ON THE CHEMICAL CONSTITUENTS FROM DESMOS DUMOSUS (ROXB.) SAFF

    摘要
  • 摘要: 目的：寻找番荔枝科假鹰爪属植物毛叶假鹰爪［Desmos dumosus (Roxb.) Saff］根抗肿瘤活性成分。方法：用硅胶柱色谱分离化学成分；UV,IR,EI-MS,1HNMR,13CNMR,1H-1H COSY,HMQC,HMBC,NOESY等方法鉴定结构。结果：从氯仿萃取物中分离鉴定了6个化合物，分别为2-甲氧基-3-甲基-4,6-二羟基-5-(3′-羟基)肉桂酰基苯甲醛(I),5-羟基-7-甲氧基-8-甲酰基-3-苯甲酰基-2,6-二甲基-2S,3R-二氢色原酮(II)，豆甾-4-烯-3,6-二酮(III),豆甾烷-3,6-二酮(IV),荠宁黄酮(V),黄芩素-7-甲醚(VI)。结论：化合物II为新化合物，命名为毛叶假鹰爪素A。I，III和IV为首次从本种植物中得到。III有细胞毒活性。

     

    Abstract: AIM: To investigate new compounds with anti-tumor activities from the roots of Desmos dumosus of annonaceae. METHODS: The chemical constituents were isolated by silica gel column chromatography, and the structures were elucidated by UV, IR, MS, 1HNMR, 13CNMR, 1H-1H COSY, HMQC, HMBC and NOESY analysis. RESULTS: Six compounds have been isolated from the CHCl3 extract of this plant. They were identified as 2-methoxy-3-methyl-4,6-dihydroxy-5(3′-hydroxyl) cinnamoylbenzaldehyde (I), 5-hydroxy-7-methoxy-8-formyl-3-benzoyl-2,6-dimethyl-2S,3R-dihydrochromone (II), stigmast-4-ene-3,6-dione (III), stigmastane-3,6-dione (IV), mosloflavone (V) and negletein (VI). CONCLUSION: Compound II, named desmosdumotin A, is a new compound. I, III and IV were found from this plant for the first time. III showed cytotoxic activities.

     

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