九里香化学成分的研究

STUDEIS ON THE CONSTITUENTS OF MURRAYA PANICULATA (L.) JACK.

摘要: 自广东产芸香科(Rutaceae)植物九里香(Murraya paniculata(L.)Jack.)叶中分离得到六个香豆精,其中三个化合物为新的香豆精,根据光谱(UV,IR,NMR和MS)分析和化学方法确定九里香甲素(isomexoticin)九里香乙素(murpanidin)和九里香丙素(murpanicin)分别为(一)5,7-二甲氧基-8-(2′,3′-二羟基-3′-甲基丁基)香豆精(Ⅰ),(+)7-甲氧基-8-(1′,2′-二羟基-3′-甲基-3′-丁烯基香豆精(Ⅲ)和7-甲氧基-8-(1′-乙氧基-2′-羟基-3′-甲基-3′-丁烯基)香豆精(Ⅳ)。同时也得到三个已知香豆精murragatin(Ⅱ),murralongin(Ⅴ)和5,7-二甲氧基-8-(3′-甲基-2′-酮基丁基)香豆精(Ⅵ),最后一个是首次自本植物中得到的。

Abstract: Six coumarins were isolated from the leaves of Murraya paniculata (L.) Jack. (Rutaceae) grown in Guangdong. Three of the coumarins are new. On the basis of spectroscopic (UV, IR, NMR and MS) analysis and chemical methods isomexoticin, murpanidin and murpanicin were identified as (-) 5,7-dimethoxy-8-(2,3-dihydroxy-3-methylbutyl) coumarin (Ⅰ), (+) 7-methoxy-8-(1,2-dihydroxy-3-methyl-3-butenyl) coumarin (Ⅲ) and 7-methoxy-8-(1-ethoxy-2-hydroxy-3-methyl-3-butenyl) coumarin (Ⅳ), respectively. In addition, three known coumarins, murragatin (Ⅱ), murralongin (Ⅴ) and 5,7-dimethoxy-8-(3-methyl-2-keto-butyl) coumarin (Ⅵ), were also obtained. The last compound was isolated for the first time from this plant.