叶发青, 丁友梅, 陈莉, 叶松, 陈志祥. 环丙沙星衍生物的合成及抗菌活性研究J. 药学学报, 2005, 40(2): 132-135.
引用本文: 叶发青, 丁友梅, 陈莉, 叶松, 陈志祥. 环丙沙星衍生物的合成及抗菌活性研究J. 药学学报, 2005, 40(2): 132-135.
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YE Fa-qing, DING You-mei, CHEN Li, YE Song, CHEN Zhi-xiang. Synthesis and antibacterial activity of ciprofloxacin derivativesJ. Acta Pharmaceutica Sinica, 2005, 40(2): 132-135.
Citation: YE Fa-qing, DING You-mei, CHEN Li, YE Song, CHEN Zhi-xiang. Synthesis and antibacterial activity of ciprofloxacin derivativesJ. Acta Pharmaceutica Sinica, 2005, 40(2): 132-135.
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环丙沙星衍生物的合成及抗菌活性研究

Synthesis and antibacterial activity of ciprofloxacin derivatives

    摘要
  • 摘要: 目的研究环丙沙星衍生物的合成及其抗菌活性。方法采用2-甲基-5-硝基咪唑、环丙沙星等为原料,通过亲核取代反应合成目的物；测定目的物的抗菌活性。结果设计、合成了9个新化合物,其结构经MS,1H NMR和元素分析确证。化合物II, IVC和 IVD的体内抗菌活性较明显。结论化合物II, IVC和 IVD显示了一定的体内抗菌活性,值得进一步研究。

     

    Abstract: AimTo study the synthesis and antibacterial activity of ciprofloxacin derivatives. MethodsCiprofloxacin derivatives were synthesized primarily from 2-methyl-5-nitroimidazol and ciprofloxacin through nucleophilic substitution. The antibacterial activity of the synthesized compounds were tested. ResultsNine new compounds were synthesized. The structure of the title compounds were confirmed by 1H NMR, MS and element analysis. ConclusionCompounds II, IVC and IVD showed appreciable antibacterial activity ,and were worth further studying.

     

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