滇钩藤化学成份研究

STUDIES ON THE CHEMICAL CONSTITUENTS OF UNCARIA YUNANENSIS HSIA.C.C

摘要: 目的　研究滇钩藤(Uncaria yunnanensis Hsia.C.C)根的化学成分。方法　运用各种色谱技术进行分离,用IR,MS,¹HNMR,¹³CNMR,2DNMR等光谱技术鉴定化合物。结果　得到7个化合物,分别鉴定为:3β,6β,19α-三羟基乌苏酸(I),23,-去甲基24烯-3β,6β,19α-乌苏酸(II),6β,19α-二羟基-乌苏酸-3-酮(III),齐墩果酸(IV),5,7,3′,4′-四羟基-黄烷-3-醇(V),β-育亨宾(VI)和滇钩藤碱I(VII)。结论　VII为新化合物,其余化合物均为首次从该植物中分得。

Abstract: AIM　To research the chemical constituents from dried roots of Uncaria yunanensis Hsia.C.C. METHODS　Modern chromatography was used to isolate chemical components. Their structure were identified by spectral analysis. RESULTS　Seven compounds were isolated and identified as 3β,6β,19α-trihydroxyurs-12-en-28 oic acid (I), 23-nor-24-esomethylene-3β,6β-19α-trihydroxyurs-12-en-28 oic acid (II), 3-oxo-6β,19α-dihydroxyurs-12-en-28 oic acid (III), oleanic acid (IV), 5,7,3′,4′-tetrahydroxy-flavan-3-ol (V), β-yohimbine (VI) and diangoutengjian I (VII). CONCLUSION　All of the above compounds were isolated for the first time from the root of this plant. Among them, compound VII is a new one.