Abstract: AimTo search for new compounds for the treatment of cardiovascular diseases by structural modification of cyclovirobuxine D． MethodsAccording to rational drug design principle， a series of cyclovirobuxine D analogues were prepared， and their bioactivities were tested． ResultsTen new compounds were syntheized and confirmed by spectra． ConclusionEndurance lacking oxygen activity and antiarrhythmia effects of some analogues of cyclovirobuxine D were tested． Some compounds showed better activity than cyclovirobuxine D．