海南青牛胆生物碱的研究

STUDIES ON ALKALOIDS FROM TINOSPORA HAINANENSIS

摘要: 目的:研究海南青牛胆(Tinospora hainanensis H.S.Lo et Z.X.Li) 藤茎中的生物碱成分。方法:用溶剂提取及硅胶柱色谱分离纯化化学成分,通过 MS, NMR, HMQC, HMBC 及X-ray 测定结构。结果:3种季铵生物碱以碘化物形式被分离并鉴定为: 非洲防己碱(colu mba mine ,I)、S-反式-N-甲基四氢非洲防己碱(S-trans-N-m ethyltetrahydrocolu mbamine , II) 及 S-反式-轮环藤酚碱(S-trans-cyclanoline , III) 。结论: I I I是新生物碱。

Abstract: AIM： To study the alkaloidal constituents of the vine stalk of Tinospora hainanensis. METHODS: Using solvent extraction and silica gel column chromatography to separate and purify the chemical constituents. MS, NMR, HMQC, HMBC and X-ray were used to determine the structure of the isolated constituents. RESULTS: Three quaternary alkaloids in the form of iodide were isolated and identified as: columbanine (I), S-trans-N-methyltetrahydrocolumbamine (II) and S-trans-cyclanoline (III). CONCLUSION: III is a new alkaloid.