中国乌头之研究——ⅩⅪ.赣皖乌头的研究

STUDIES ON THE CHINESE DRUG, ACONIITUM SPP——ⅩⅪ. ALKALOIDS FROM ACONITUM FINETIANUM HAND-MAZZ

摘要: 从赣皖乌头(Aconitum finetianum Hand-Mazz)中又分得五个生物碱,经光谱及化学方法鉴定,其中二个为新的二萜类生物碱,即脱乙酰冉乌头碱(N-deacetylranconitine),C₃₀H₄₂N₂O₆,熔点125～127℃,和脱乙酰赣乌碱(N-deacetylfinaconitine),C₃₀H₄₂N₂O₉,熔点121～123℃,及三个已知生物碱,即阿娃乌头碱(avadharidine)、牛扁次碱(lycoctonine)和脱乙酰刺乌头碱(N-deacetyllappaconitine)。经药理试验表明,脱乙酰冉乌头碱,脱乙酰赣乌碱和脱乙酰刺乌头碱均具有良好的镇痛效果。

Abstract: Two new alkaloids, N-deacetylranaconitine, C₃₀H₄₂N₂O₈, mp 125～127℃; and Ndeacetylfinaconitine, C₃₀H₄₂N₂O₉, mp.121—123℃, and three known alkaloids, avadharidine, lycoctonine and N-deacetyllappaconitine have been isolated from the root of Aconitum finetianum Hand-Mazz.The chemical structures of N-deacetylranaconitine and N-deacetylfinaconitine were estabished by UV, IR, NMR and MS spectral data and chemical evidences.In animal experiments, N-deacetylranaconitine, N-deacetylfinaconitine and N-deacetyllappaconitine exhibited strong analgesic activity.