月腺大戟根中的乙酰间苯三酚类衍生物

王文祥; 丁杏苞

月腺大戟根中的乙酰间苯三酚类衍生物

ACETOPHENONE DERIVATIVES FROM EUPHORBIA EBRACTEOLATA HAYATA

摘要

摘要: 目的:研究月腺大戟根中的乙酰间苯三酚类衍生物。方法:利用硅胶柱色谱分离、纯化乙酰间苯三酚类化合物;经化学反应、理化常数测定和波谱分析等鉴定结构。结果:分离得到5个乙酰间苯三酚类化合物:2,4-二羟基-6-甲氧基-3-甲基苯乙酮(I),3,3′-二乙酰基-4,4′-二甲氧基-2,2′,6,6′-四羟基二苯甲烷(I),3,3′-二乙酰基-4,4′-二甲氧基-2,2′,6,6′-四羟基二苯甲烷-6′-O-β-D-葡糖苷(II),2,4-二羟基-6-甲氧基-3-甲基苯乙酮-4-O-β-D-葡糖苷(IV),2,4-二羟基-6-甲氧基-3-甲基苯乙酮-4-O-β-D-木糖基(1→6)-O-β-D-葡糖苷(V)。结论:(II)和(V)为新化合物,分别命名为月腺大戟苷B和月腺大戟苷C。

Abstract: AIM: To study the acetophenone derivatives from Euphorbia ebracteolata Hayata. METHODS: Acetophenone derivatives were isolated and purificated with silica gel chromatography, their chemical structures were elucidated by their physicochemical properties and spectral data. RESULTS: Five acetophenone derivatives were isolated from this plant as the following: 2,4 dihydroxy-6-methoxy-3-methylacetophenone (I), 3,3′-diacetyl-4,4′-dimethoxy- 2,2′,6,6′-tetrahydroxy diphenylmethane (II), 3,3′-diacetyl-4,4′-dimethoxy-2,2′,6,6′-tetrahydroxy diphenyl methane- 6′-O-β-Dglusopyranoside (III), 2,4-dihydroxy-6-methoxy-3-methylacetophenone-4-O-β-D-glucopyranoside (IV) and 2,4dihydroxy-6-methoxy-3-methyl acetophenone-4-Oβ-D-xylopyranosyl (1→6)-β-D- glucopyranoside (V).CONCLUSION: Compounds III and V are new compounds, named ebractelatinoside B and ebractelatinoside C respectively.

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