Abstract: AimTo develop high bioavailability preparations without irritation for Panax notoginsenosides. MethodsThe effects of some additives such as microcrystalline cellulose, β-cyclodextrin and hydroxypropyl cellulose on drug in the preparations were examined. ResultsSaponins of Panax notoginseng (PNS) was absorbed in rabbits more when administered intranasally than through other routines, and the formulations including MCC both gave high bioavailability and low irritation. ConclusionBioavailability of Panax notoginsenosides can be increased through changing routine of administration and formulations.