EV71非结构蛋白的结构和功能及其为靶点的药物研究进展

Advances in functional studies of nonstructural proteins and development of antiviral agents for enterovirus 71

摘要:
近年肠道病毒71型 (EV71) 等引起的手足口病在中国大陆呈现上升的流行趋势, 其正链的RNA基因组翻译成一个多聚蛋白, 进一步自剪切为结构蛋白和非结构蛋白; 随着研究的深入, 非结构蛋白在病毒生命周期中的功能逐一被鉴定, 本文就EV71非结构蛋白的结构功能及针对这些靶点的抗病毒药物进行综述。

Abstract:
Human enterovirus 71 (EV71) is one of the major etiological agents for the hand, foot, and month disease (HFMD) and is causing frequent, widespread occurrence in the mainland of China. The single positive- stranded RNA genome of EV71 is translated into a single polyprotein which is autocleavaged into structural and nonstructural proteins. The functions of many nonstructural proteins characterized in the life cycle of virus are potential targets for blocking viral replication. This article reviews the studies of the structures and functions of nonstructural proteins of EV71 and the anti-enterovirus 71 drugs targeting on these nonstructural proteins.