孟怡, 顾娟. 应用13C核磁共振INEPT方法测定5α-氯-16-次甲基-3β,6β,17α-三羟基-孕甾-20-酮-3β,17α二醋酸酯的结构J. 药学学报, 1988, 23(4): 288-292.
引用本文: 孟怡, 顾娟. 应用13C核磁共振INEPT方法测定5α-氯-16-次甲基-3β,6β,17α-三羟基-孕甾-20-酮-3β,17α二醋酸酯的结构J. 药学学报, 1988, 23(4): 288-292.
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Y Meng, J Gu. APPLICATION OF 13CNMR INEPT TECHNIQUE TO STRUCTURE DETERMINATION OF 5α-CHLORINE-16-METHYLENE-3β,6β,17α-TRIHYDROXYPREGNAN-20-ONE-3,17-DIACETATEJ. Acta Pharmaceutica Sinica, 1988, 23(4): 288-292.
Citation: Y Meng, J Gu. APPLICATION OF 13CNMR INEPT TECHNIQUE TO STRUCTURE DETERMINATION OF 5α-CHLORINE-16-METHYLENE-3β,6β,17α-TRIHYDROXYPREGNAN-20-ONE-3,17-DIACETATEJ. Acta Pharmaceutica Sinica, 1988, 23(4): 288-292.
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应用13C核磁共振INEPT方法测定5α-氯-16-次甲基-3β,6β,17α-三羟基-孕甾-20-酮-3β,17α二醋酸酯的结构

APPLICATION OF 13CNMR INEPT TECHNIQUE TO STRUCTURE DETERMINATION OF 5α-CHLORINE-16-METHYLENE-3β,6β,17α-TRIHYDROXYPREGNAN-20-ONE-3,17-DIACETATE

    摘要
  • 摘要: 应用质子去偶及质子偶合INEPT方法测定药物合成中间体(Ⅱ)的结构。与宽带质子去偶及门控去偶方法比较,INEPT方法具有较高的灵敏度和选择性,节省实验时间。

     

    Abstract: 5α-Chlorine-16-methylene-3β, 6β, 17α-trihydroxypregnan-20-one 3, 17-diacetate has been examined to confirm the key structure using proton deeoupled and coupled INEPT technique. By comparison with the proton broadband decoupling and gated deccupling assignment techniques, the INEPT methods showed higher sensitivity, selectivity and time-efficiency.

     

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