张婷婷, 马辰. 奥利司他中有关物质的UPLC-MS/MS研究J. 药学学报, 2014,49(3): 380-384.
引用本文: 张婷婷, 马辰. 奥利司他中有关物质的UPLC-MS/MS研究J. 药学学报, 2014,49(3): 380-384.
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ZHANG Ting-ting, MA Chen. Related substances in orlistat detected with UPLC-MS/MSJ. Acta Pharmaceutica Sinica, 2014,49(3): 380-384.
Citation: ZHANG Ting-ting, MA Chen. Related substances in orlistat detected with UPLC-MS/MSJ. Acta Pharmaceutica Sinica, 2014,49(3): 380-384.
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奥利司他中有关物质的UPLC-MS/MS研究

Related substances in orlistat detected with UPLC-MS/MS

    摘要
  • 摘要: 采用超高压液相色谱-质谱联用技术（UPLC-MS/MS），研究国内部分厂家的奥利司他原料药中有关物质的结构，确定了奥利司他10种有关物质的结构式或相对分子质量。获得并比较了不同来源的奥利司他原料药中的有关物质结构信息，为其开发及质量监控提供有意义的实验数据和参考依据。

     

    Abstract: The study aims to identify related substances in orlistat pharmaceutical substance from different production technologies. Advanced technologies including UPLC-QTOF-MS and UPLC-QTrap-MS were used and the structures or molecules of 10 kinds of related substances in orlistat were identified. The experimental data were valuable to the quality control and development of orlistat.

     

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