刘勇林, 李晨旭, 邱芸, 邱学才. 脑室注射硝普钠、L-精氨酸、NG-硝基-L-精氨酸对清醒状态大鼠心血管活动的影响J. 药学学报, 1997, 32(1): 11-11.
引用本文: 刘勇林, 李晨旭, 邱芸, 邱学才. 脑室注射硝普钠、L-精氨酸、NG-硝基-L-精氨酸对清醒状态大鼠心血管活动的影响J. 药学学报, 1997, 32(1): 11-11.
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YL Liu, CX Li, Y Qiu , XC Qiu, . INFLUENCE OF INTRACEREBROVENTRICULAR INJECTION OF SODIUM NITROPRUSSIDE L-ARGININE AND NG-NITRO-L-ARGININE ON CARDIOVASCULAR ACTIVITY IN CONSCIOUS RATSJ. Acta Pharmaceutica Sinica, 1997, 32(1): 11-11.
Citation: YL Liu, CX Li, Y Qiu , XC Qiu, . INFLUENCE OF INTRACEREBROVENTRICULAR INJECTION OF SODIUM NITROPRUSSIDE L-ARGININE AND NG-NITRO-L-ARGININE ON CARDIOVASCULAR ACTIVITY IN CONSCIOUS RATSJ. Acta Pharmaceutica Sinica, 1997, 32(1): 11-11.
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脑室注射硝普钠、L-精氨酸、NG-硝基-L-精氨酸对清醒状态大鼠心血管活动的影响

INFLUENCE OF INTRACEREBROVENTRICULAR INJECTION OF SODIUM NITROPRUSSIDE L-ARGININE AND NG-NITRO-L-ARGININE ON CARDIOVASCULAR ACTIVITY IN CONSCIOUS RATS

    摘要
  • 摘要: 给大鼠侧脑室内注射(icv)硝普钠(SNP)、NO的前体物质L-精氨酸(L-Arg)和精-精二肽(Arg-Arg),NO合成酶(NOS)抑制剂NG-硝基-L-精氨酸(NNLA),观察清醒状态大鼠血压和心率的变化,探讨脑内NO对清醒状态大鼠心血管活动的调节作用。实验结果表明,icvSNP(8,16,32μg)使血压升高,并呈剂量效应关系,同时使心率加快。icvL-Arg(200μg)或不同剂量的精-精二肽也使血压升高,心率加快;icvNNLA(100μg)则使血压下降,心率减慢。以上结果提示,在一定范围内提高脑内NO,对心血管活动有正性调节作用,降低脑内NO则对心血管活动有负性调节作用。

     

    Abstract: In order to study the cardiovascular effect of NO in conscious rats, sodium nitroprusside(SNP), the precursor of NO(L-Arginine, Arg-Arg) and one of the inhibitor of NOS (NG nitro L-arginine, NNLA) were intracerebroventricularly(icv) injected. Our experimental results indicated that, an apparant dose-dependent hypertensive effect was produced by icv administration of SNP (8, 16, 32 and 32 μg), a tachycardiac effect was also produced at the same time. In addition, hypertention and tachycardia were produced by icv L-arginine and the dipeptide Arg-Arg. Futhermore. a hypotensive and bradycardiac effect can be produced by icv NNLA. These results suggest that there is a positive effect on cardiovascular activity due to increase of endogeneuse NO in the rat brain and a negative effect on cardiovascular activity due to decrease of endogeneuse NO in the rat brain.

     

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