A series of 2-substituted-((N, N-disubstituted)-1, 3-benzoxazole)-5-carboxamides derivatives were synthesized by the reaction of 2-substituted-5-carbomethoxy benzoxazole with different secondary amines.  The newly synthesized compounds were characterized on the basis of spectral (FT-IR, ¹H NMR, MS) & elemental analysis.  All these compounds were screened for anti-inflammatory activity using carrageenan induced rat paw edema method.  All of these compounds exhibited significant activity.  Among the tested compounds Ve, Vg, Vf and Va were considered to have potent anti-inflammatory activity and was comparable with standard.