刘晓曼, 李嘉丽, 王洪阳, 傅茜, 李军, 刘澍, 孙萍萍, 王长希, 黄民. SUMO4基因多态性与肾移植患者他克莫司浓度相关性的研究J. 药学学报, 2015,50(2): 180-184.
引用本文: 刘晓曼, 李嘉丽, 王洪阳, 傅茜, 李军, 刘澍, 孙萍萍, 王长希, 黄民. SUMO4基因多态性与肾移植患者他克莫司浓度相关性的研究J. 药学学报, 2015,50(2): 180-184.
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LIU Xiao-man, LI Jia-li, WANG Hong-yang, FU Qian, LI Jun, LIU Shu, SUN Ping-ping, WANG Chang-xi, HUANG Min. Associations of SUMO4 polymorphisms with tacrolimus concentrations in Chinese renal transplant recipientsJ. Acta Pharmaceutica Sinica, 2015,50(2): 180-184.
Citation: LIU Xiao-man, LI Jia-li, WANG Hong-yang, FU Qian, LI Jun, LIU Shu, SUN Ping-ping, WANG Chang-xi, HUANG Min. Associations of SUMO4 polymorphisms with tacrolimus concentrations in Chinese renal transplant recipientsJ. Acta Pharmaceutica Sinica, 2015,50(2): 180-184.
shu

SUMO4基因多态性与肾移植患者他克莫司浓度相关性的研究

Associations of SUMO4 polymorphisms with tacrolimus concentrations in Chinese renal transplant recipients

    摘要
  • 摘要: 考察小泛素相关修饰蛋白4(SUMO4)的单核苷酸多态性(SNP)与肾移植患者术后早期他克莫司浓度之间的相关性。共纳入132例中国肾移植术后患者, 采用Sequenom® MassARRAY system对SUMO4(rs237024, rs237025)进行基因分型, 聚合酶链反应-限制性片段长度多态性(PCR-RFLP)法对CYP3A5*3进行基因分型, 并分析上述基因型对他克莫司浓度的影响。结果显示, SUMO4基因rs237024与rs237025位点间存在完全连锁不平衡(D'=1)。SUMO4 rs237024A-rs237025A型组(GA-GA型+AA-AA型)他克莫司剂量校正浓度显著高于GG-GG型组(P<0.05)。以CYP3A5*3基因型进行分层后, 在表达型组中SUMO4 rs237024A-rs237025A型组(GA-GA型+AA-AA型)他克莫司剂量校正浓度显著高于GG-GG型组(P<0.05)。肾移植术后患者SUMO4 rs237024、rs237025基因多态性与他克莫司浓度相关, 该基因型检测将有助于指导他克莫司的临床个体化用药。

     

    Abstract: The study aims to investigate the associations of SUMO4 polymorphisms with tacrolimus concentrations in Chinese renal transplant recipients. Blood samples and clinical data were collected from 132 renal transplant recipients with tacrolimus treatment. CYP3A5*3 genotypes were detected by PCR-RFLP, and SUMO4 (rs237024, rs237025) genotypes were detected by Sequenom® MassARRAY system. SUMO4 rs237024 and rs237025 genotypes were in complete linkage disequilibrium (D'=1). The dose-adjusted concentration of tacrolimus in SUMO4 rs237024A-rs237025A (GA-GA+AA-AA) carriers was considerably higher than that in GG-GG carriers (P<0.05). After stratification by CYP3A5*3 genotypes, SUMO4 rs237024A-rs237025A carriers (GA-GA+AA-AA) had a higher dose-adjusted tacrolimus concentration than that in GG carriers in CYP3A5 expresser (P<0.05). The results illustrated that SUMO4 rs237024 and rs237025 polymorphisms were associated with tacrolimus concentrations, and the test of these genotypes may be useful for individualized medicine of tacrolimus.

     

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