钟三保, 刘维勤, 李仁利, 凌仰之, 李重华, 涂光忠, 马立斌, 洪少良. 三尖杉酯类生物碱的半合成及结构与抗肿瘤活性的关系J. 药学学报, 1994, 29(1): 33-38.
引用本文: 钟三保, 刘维勤, 李仁利, 凌仰之, 李重华, 涂光忠, 马立斌, 洪少良. 三尖杉酯类生物碱的半合成及结构与抗肿瘤活性的关系J. 药学学报, 1994, 29(1): 33-38.
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SB Zhong, WC Liu, RL Li．YZ Ling, CH Li, GZTu, LB Ma , SL Hong, . STUDIES ON SEMI—SYNTHESIS OF CEPHALOTAXINE ESTERS AND CORRELATION OF THEIR STRUCTURES WITH ANTITUMOR ACTIVITYJ. Acta Pharmaceutica Sinica, 1994, 29(1): 33-38.
Citation: SB Zhong, WC Liu, RL Li．YZ Ling, CH Li, GZTu, LB Ma , SL Hong, . STUDIES ON SEMI—SYNTHESIS OF CEPHALOTAXINE ESTERS AND CORRELATION OF THEIR STRUCTURES WITH ANTITUMOR ACTIVITYJ. Acta Pharmaceutica Sinica, 1994, 29(1): 33-38.
shu

三尖杉酯类生物碱的半合成及结构与抗肿瘤活性的关系

STUDIES ON SEMI—SYNTHESIS OF CEPHALOTAXINE ESTERS AND CORRELATION OF THEIR STRUCTURES WITH ANTITUMOR ACTIVITY

    摘要
  • 摘要: 报道10个氨基酸三尖杉碱醋类衍生物的半合成及抗肿瘤活性,药理实验结果表明,化合物6有显著的抗癌活性,其它化合物亦有不同程度的抗癌活性。通过化学结构与抗癌作用的比较,初步探讨了此类生物碱的构效关系。

     

    Abstract: Ten esters of cephalotaxine with amino acids possessing widely different structuralfeatures have been synthesized and tested for antitumor activity. Prelimary data showed that com-pound 6 is the most active one. However it is still less potent than harringtonine,Other syntheticesters possess varying activities at 1 0μg/ml.Preliminary structure activity relationship of these esterswas discussed.

     

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