Abstract: The therapeutic effect of coadministration of pyquiton and furapromidum to infect-ed mice was slightly greater than the sum of the effects of the two drugs given indi-vidually. The efficacy of the combined treatment of infected rabbits exhibited a mark-ed synergistic action. Hepatic shift of schistosomes was observed in infected rabbits fol-lowing the intramuscular injection of pyquiton at 5 mg/kg, which was not lethal to worms, and over 90% of the female worms remained in the liver 24 hours after the medication. When infected rabbits were treated intramuscularly with pyquiton at 5 mg/kg/day×1 in combination with oral furapromidum at 60 mg/kg/day×4, the average reduction rate of the female worms reached 95% and a part of the rabbits were free from female worms. With pyquiton at the dosage regime of 10 mg/kg/day×1, given jointly with oral furapromidum at 30 mg/kg/day×4, the same results were obtained. The therapeutic efficacy of coadministration of pyquiton and furapromidum was much higher than that of dipterex and furapromidum.Within the dosage levels used in the experiments, the coadministration of pyquitou and furapromidum displayed neither additive nor synergistic toxic action, as assessed by LD₅₀ and the Evans blue test of mouse stomach.