Abstract: The anticonvulsant and analgesic activities of the extract of Tian-Ma, a traditional Chinese medicine, were studied in mice. 1. Anticonvulsant activity: Generalized clonic convulsions and loss of the upright posture were regularly elicited in mice by the rapid i.v. injection of 33mg/kg (CD96) of a 0.5% aqueous solution of metrazol into the dorsal tail vein. Tian-Ma extract (10%) in doses of 0.2—0.5ml/10g. given intraperitoneally 30 min. before the administration of metrazol showed a marked suppressive effect on the development of the clonic seizure, and in those animals that developed convulsions, the latent period was significantly prolonged. This protective effect reached its peak at 30—60 min. following the administration of the extract. Thereafter, it gradually decreased, and by the end of 4 hours, the anticonvulsant activity was reduced to nearly one half. 2. Analgesic activity: The modified method of Reinhard de Beer Grewal was followed. The results obtained revealed that even relatively large dose of Tian-Ma extract given intraperitoneally did not show any marked analgesic activity. 3. Acute toxicity: The LD₅₀ of intraperitoneally administered Tian-Ma extract for male adult mice (allowed free access to food and water) and female adult mice (withdrawal of food 8 hours before experiment) were 61.4g (crude drug)/kg. and 51.4 g (curde drug)/kg. respectively, indicating that the toxicity of Tian-Ma is of low order.