Abstract: Cerebral anoxia is induced by fastening a pneumatic cuff around the neck of the rabbit and inflating maximally to interrupt the hrain circulation. This results in disappearance of brain waves in EEG. The time interval between the occlusion of the carotid vessels and the disappearance of brain waves is taken as the time of tolarance to cerebral hypoxia. The efficacy of a drug is evaluated by comparing the tolerance time before and after drug administration. The perentages of increase of tolerance time, measured at 10 minutes intervals, after a slow bolus I.V. injection of pentobarbitone sodium 20 mg/kg were found to be 52.5%, 46.5%, 36.4%; 29.2% and 16.1%. ATP (20 mg I.V.) also showed significant increase of tolerance time to a maximum of 50.4%.This method is simple and reliable, requiring relatively few animals and is suitable for large scale screening of anti-cerebral anoxia drugs. It may also be used for the study of cerebral physiological functions.