蛋白磷酸酶1对HIV-1转录的调节作用及其抑制剂研究

Action of protein phosphatase-1 on Tat-dependent HIV-1 transcription and its related inhibitors

摘要:
宿主细胞蛋白-蛋白磷酸酶1 (PP1) 是人类免疫缺陷病毒1型 (human immunodeficiency virus-1, HIV-1) 转录的调节因子之一, 参与HIV-1转录。脱磷酸化cyclin T1依赖性激酶9 (CycT1-dependent kinase 9, CDK9) 或RNA聚合酶ⅡC末端区 (RNAPII CTD) 以增强Tat诱导的转录。本文综述了PP1在HIV-1转录过程的作用及其抑制剂研究进展。

Abstract:
Host cell protein phosphatase-1 (PP1) is an important regulator of human immunodeficiency virus-1 (HIV-1) transcription. PP1 is involved in the regulation of HIV-1 transcription, and dephosphorylates RNA polymerase II C-terminal domain (RNAPII CTD) or CycT1-dependent kinase 9 (CDK9) to increase Tat- dependent HIV-1 transcription. In this review, we discuss the action of PP1 in Tat-induced HIV-1 transcription and related to PP1 inhibitors.