羊红膻根中羊红膻素A及羊红膻素B的分离和鉴定

SEPARATION AND IDENTIFICATION OF THE LLUNGIANIN A AND B FROM THE ROOT OF PIMPINELLA THELLUNGIANA WOLFF

摘要: 从草药羊红膻(Pimpinela thelungiana Wolf)根中分得2个化合物,经光谱解析(UV,IR,MS,¹HNMR,¹H¹HCOSY,¹³CNMR,¹³C-¹HCOSY和DEPT),鉴定为2-(1-ethoxy-2-hydroxy)propyl-4-methoxyphenol(I)和2-(1-ethoxy-2-hydroxy)propyl-4-methoxyphenyl-2-methyl-butyrate(II),分别命名为羊红膻素A及羊红膻素B,为2个新的天然产物,药理实验表明这2个新化合物均有较明显的降压活性。

Abstract: Two compounds were isolated from the roots of Pimpinella thellungiana wolff. On the basis of spectral analysis (UV,IR,MS, ¹HNMR, ¹H-¹H COSY, ¹³CNMR, ¹H-¹³C COSY,DEPT), they were identified as 2-(1-ethoxy-2-hydroxy) propyl-4-methoxyphenol(I); 2-(1-ethoxy-2-hydroxy) propyl-4-methoxyphenyl-2-methyl butyrate(II). They are new compounds named the llungianin A and B. Pharmacological tests showed that they have some hypotensive effects.