东北红豆杉化学成分的分离与鉴定

Isolation and identification of chemical constituents from Taxus cuspidta Sibe et Zucc

摘要:
利用硅胶柱色谱、制备高效液相色谱等分离方法, 从东北红豆杉提取物中分离得到3个化合物。根据理化性质和波谱数据对化合物进行结构鉴定, 分别鉴定为 (E)-1-methoxy-2-O-(p-coumaroyl)-myo-inositol (1)、2- deacetoxy-7β, 9α, 10β-trideacetyltaxinine J (2) 和 (3aS, 4aR, 6S, 8S, 8aS, 9R, 10R, 10aS)-benzfazulene-6, 8, 9, 10 (3H)-terol, 3a, 4, 4a, 5, 6, 7, 8, 8a, 9, 10-decahydro-10a-(1-hydroxyl-1-methylethyl)-1, 8a-dimethyl-5-methylene (3)。其中化合物1为一新化合物, 化合物2、3为两个新天然产物。

Abstract:
Three compounds were isolated from the extract of Taxus cuspidta Sibe et Zucc with the column chromatography on silica gel and preparative HPLC methods. Their structures were identified according to the physicochemical properties and spectral analysis, and they were identified as (E)-1-methoxy-2-O-(p-coumaroyl)- myo-inositol (1), 2-deacetoxy-7β, 9α, 10β-trideacetyltaxinine J (2) and (3aS, 4aR, 6S, 8S, 8aS, 9R, 10R, 10aS)- benzfazulene-6, 8, 9, 10 (3H)-terol, 3a, 4, 4a, 5, 6, 7, 8, 8a, 9, 10-decahydro-10a-(1-hydroxyl-1-methylethyl)-1, 8a-dimethyl-5-methylene (3). Among them, compound 1 was a new compound, and compounds 2, 3 were two novel natural products.