罗时杰. 辛可芬的合成J. 药学学报, 1960, 8(1): 15-18.
引用本文: 罗时杰. 辛可芬的合成J. 药学学报, 1960, 8(1): 15-18.
Lou SHIU-JEE. SYNTHESIS OF CINCHOPHENJ. Acta Pharmaceutica Sinica, 1960, 8(1): 15-18.
Citation: Lou SHIU-JEE. SYNTHESIS OF CINCHOPHENJ. Acta Pharmaceutica Sinica, 1960, 8(1): 15-18.

辛可芬的合成

SYNTHESIS OF CINCHOPHEN

  • Abstract: The Doebner and Gieseke's method of synthesizing cinchophen was modified and further developed. In condensing 1.25 moles of benzal aniline with 1 mole of crude 50% pyruvic acid at 40℃ in alcohol, the yield increased up to 60.20% of the theory. The production of pyruvic acid was made more economical and convenient by dry distillation of tartaric acid in higher temperature.

     

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