谢晶曦, 周瑾, 张纯贞, 杨靖华, 陈葭曦, 金汉卿. 五味子丙素类似物合成的研究J. 药学学报, 1981, 16(4): 306-309.
引用本文: 谢晶曦, 周瑾, 张纯贞, 杨靖华, 陈葭曦, 金汉卿. 五味子丙素类似物合成的研究J. 药学学报, 1981, 16(4): 306-309.
Xie Jingxi, Zhou Jin, Zhang Chunzhen, Yang Jinghua , Chen Jiaxi, Jin Hanqing, . SYNTHESIS OF SCHIZANDRIN C ANALOGSJ. Acta Pharmaceutica Sinica, 1981, 16(4): 306-309.
Citation: Xie Jingxi, Zhou Jin, Zhang Chunzhen, Yang Jinghua , Chen Jiaxi, Jin Hanqing, . SYNTHESIS OF SCHIZANDRIN C ANALOGSJ. Acta Pharmaceutica Sinica, 1981, 16(4): 306-309.

五味子丙素类似物合成的研究

SYNTHESIS OF SCHIZANDRIN C ANALOGS

  • Abstract: Schizandrin C, a new component isolated from Schizandra Chinensis Baill, was found to be effective in protecting the liver from CCl4 injury.For the purpose of finding new synthetic drugs, several Schizandrin C analogs were synthesized. The intermediate compound: methyl 4,4'-dimethoxy-5, 6, 5'6'-methylenedioxybiphenyl-2,2'-dicarboxylate was found to be effective in lowering the elevated SGPT level in CCl4 intoxicated mice.The spectra data and physical constants of several analogs and intermediates (3a, 3b, 3c, 11a, 12, 15a, 8a, 18a, 23) are also reported.

     

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