毛麻楝茎皮中2个新的phragmalin柠檬苦素原酸酯

Two new phragmalin-type limonoid orthesters from Chukrasia tabularis var. velutina

摘要:
为了研究毛麻楝中结构新颖的phragmalin类型柠檬苦素成分, 运用各种色谱分离方法结合制备液相对其乙醇提取物进行了系统分离, 并得到了4个结构复杂的phragmalin类型柠檬苦素原酸酯类成分。他们的结构经一维、二维核磁共振和高分辨质谱等方法最终鉴定为 tabularin Q (1)、tabularin C (2)、tabularin H (3) 和tabulalide O (4), 其中化合物1和4为新化合物。

Abstract:
As a part of our ongoing research program to isolate novel phragmalin limonoids from the stem bark of Chukrasia tabularis var. velutina, two new phragmalin limonoids orthesters, tabularin Q (1) and tabulalide O (4), along with two known compounds tabularin C (2) and tabularin H (3) were isolated. Their structures were elucidated by means of extensive 1D and 2D spectroscopic analyses which included HSQC, HMBC, and ROESY experiments and HR-ESI-MS.