免疫佐剂—胞壁酰二肽(MDP)的合成

陈正英; 陈兰福; 龚雄麒

陈正英, 陈兰福, 龚雄麒. 免疫佐剂—胞壁酰二肽(MDP)的合成J. 药学学报, 1982, 17(6): 425-430.

引用本文:

陈正英, 陈兰福, 龚雄麒. 免疫佐剂—胞壁酰二肽(MDP)的合成J. 药学学报, 1982, 17(6): 425-430.

CHEN Zheng-ying, CHEN Lan-fu , GONG Xiong-qi, . SYNTHESIS OF N-ACETYL-MURAMYL-DIPEPTIDE——AN IMMUNOADJUVANTJ. Acta Pharmaceutica Sinica, 1982, 17(6): 425-430.

Citation:

CHEN Zheng-ying, CHEN Lan-fu , GONG Xiong-qi, . SYNTHESIS OF N-ACETYL-MURAMYL-DIPEPTIDE——AN IMMUNOADJUVANTJ. Acta Pharmaceutica Sinica, 1982, 17(6): 425-430.

免疫佐剂—胞壁酰二肽(MDP)的合成

SYNTHESIS OF N-ACETYL-MURAMYL-DIPEPTIDE——AN IMMUNOADJUVANT

摘要

摘要: 本文报道一种合成胞壁酰二肽的方法,即不需制备光学活性纯的带保护基的胞壁酰二肽,而以其α-和β-端基异构体的混合物作为制备MDP的中间体。

Abstract: A modified method for synthesis of N-acetyl-muramyl dipeptide (MDP) is described. MDP was prepared directly from the mixture of α-and β-anomers of protected N-acetyl-muramyl dipeptide. Since the product per se is an anomeric mixture, thus obviating the use of pure anomeric starting materials in the literature.

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