非诺洛芬钙亲水凝胶缓释骨架片释药机理的研究

STUDY ON THE RELEASE MECHANISM OF FENOPROFEN CALCIUM FROM HYDROPHILLIC SUSTAINED-RELEASE MATRIX

摘要: 目的　研究非诺洛芬钙亲水凝胶缓释骨架片的释放机理。方法　以羟丙基甲基纤维素(HPMC)为亲水骨架材料，通过对Peppas经验式中n值的详细考察，研究非诺洛芬钙缓释骨架片在不同条件下的溶蚀度与释放度。结果　在各种条件下，非诺洛芬钙骨架片的释放与溶蚀均呈零级动力学过程，且二者间呈线性关系。结论　非诺洛芬钙骨架片的释放机理为:前40min，以扩散和溶蚀协同作用方式释放；50min后，以溶蚀机制释放。

Abstract: AIM　To study the release mechanism of fenoprofen calcium (FC) from hydroxypropylmethylcell- ulose (HPMC) matrices. METHODS　The release of FC and the erosion properties of hydrophillic matrices containing HPMC was examined at different paddle speed. The release mechanism of FC was further confirmed by evaluating the n value in Peppas equation. RESULTS　The results indicate that the release of FC and the erosion of matrices exhibit zero order kinetic equation, and it exhibits line relationship between them. CONCLUSION　In the first 40 min, FC mainly released by diffusion and erosion from HPMC matrix, while it was controlled by the rate of tablet erosion after 50 min.