维A类化合物4-APR抑制肿瘤侵袭、转移的作用

INHIBITION OF TUMOR INVASION AND METASTASIS BY RETINOID 4-APR

摘要: 用体内外实验模型,研究了新维A类化合物4-乙酰胺苯基维A酸酯(4-APR)对肿瘤侵袭、转移的抑制作用。4-APR 43.3mg·kg^-1po即能减少小鼠Lewis肺癌的自发性肺转移瘤数。半体内实验证明4-APR10^-5mol·L^-1和10^-6mol·L^-1对B16-F10癌细胞的人工肺转移瘤数分别抑制67.9%和36.6%。体外实验显示,4-APR对B16-F10细胞侵袭重组基底膜的抑制率分别为54.2%和41.9%。

Abstract: The anti invasive and anti metastatic effects with new retinoid 4-acetamidophenyl retinoate(4-APR) were studied using in vitro and in vivo experiments. 4-APR, at the dose of 43.3 mg·kg^-1 ·day^-1 po, was shown to reduce the spontaneous lung metastatic foci of Lewis lung carcinoma. 4-APR was also found to inhibit the artificial lung metastasis of B16-F10 cells by 67.9% and 36.6% and suppress the reconstituted basement membrane invasion of B16-F10 cells by 54.2% and 41.9% at the concentrations of 10^-5 mol·L^-1 and 10^-6 mol·L^-1, respectively.