张志强, 张沅, 王本祥, 周海欧, 王岩, 张宏. 鹿茸多肽的纯化和鉴定(英文)J. 药学学报, 1992, 27(5): 321-324.
引用本文: 张志强, 张沅, 王本祥, 周海欧, 王岩, 张宏. 鹿茸多肽的纯化和鉴定(英文)J. 药学学报, 1992, 27(5): 321-324.
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ZQ Zhang, Y Zhang, BX Wang, HO Zhou, Y Wang, H Zhang. PURIFICATION AND PARTIAL CHARACTERIZATION OF ANTI-INFLAMMATORY PEPTIDE FROM PILOSE ANTLER OF CERVUS NIPPON TEMMINCKJ. Acta Pharmaceutica Sinica, 1992, 27(5): 321-324.
Citation: ZQ Zhang, Y Zhang, BX Wang, HO Zhou, Y Wang, H Zhang. PURIFICATION AND PARTIAL CHARACTERIZATION OF ANTI-INFLAMMATORY PEPTIDE FROM PILOSE ANTLER OF CERVUS NIPPON TEMMINCKJ. Acta Pharmaceutica Sinica, 1992, 27(5): 321-324.
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鹿茸多肽的纯化和鉴定(英文)

PURIFICATION AND PARTIAL CHARACTERIZATION OF ANTI-INFLAMMATORY PEPTIDE FROM PILOSE ANTLER OF CERVUS NIPPON TEMMINCK

    摘要
  • 摘要: 应用凝胶过虑和离子交换层析等技术,从鹿茸(pilose antler or Cervus nipponTemminck)中分离纯化出一种多肽(peptide of pilose antler,PAP)。经高效液相色谱和N-末端氨基酸分析鉴定为单一多肽,氨基酸组成分析证明,PAP是由68个氨基酸组成,分子是为7200。药理研究证明,PAP对大鼠角叉菜胶性足肿胀具有明显的抑制作用并呈现良好的量—效关系。

     

    Abstract: An anti- inflammatory compound was purified and isolated from pilose ant-ler of Cervus nippon Temminck by dialysis, gel filtration and ion-exchange chromatographytechniques. HPLC and N-terminal amion acid analysis identified the compound as a homoge-neous peptide.The peptide is composed of 68 amino acids and its molecular weight,as determinedby amino analysis, is about 7200.

     

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