红豆杉愈伤组织中紫杉烷类成分sinenxan A的微生物转化研究

Microbial transformation of sinenxan A, a rich constituent in callus cultures of Taxus

摘要: 目的研究紫杉烷类化合物sinenxan A的微生物转化情况。方法分别利用两株真菌（刺囊毛霉AS 3.345 0、刺孢小克银汉霉AS 3.340 0）和一株细菌（普通变形菌AS 1.120 8）对sinenxan A进行生物转化。结果得到3个转化产物，分别为10-去乙酰-sinenxan A1, 6α-羟基-10-去乙酰sinenxan A2, 9α-羟基-10-去乙酰sinenxan A3。结论Sinenxan A易被微生物转化，10位乙酰基化学性质比较活泼。

Abstract: AimTo study the microbial transformation of sinenxan A. MethodsChoose two strains of Fungi (Mucor spinosus AS 3.345 0 and Cunninghamella echinulata AS 3.340 0) and a strain of bacterium (Proteus vulgaris AS 1.120 8) to transform the substrate. ResultsThree products were obtained and identified as 10-deacetylsinenxan A1, 6α-hydroxy-10-deacetylsinenxan A2 and 9α-hydroxy-10-deacetylsinenxan A3 respectively. ConclusionSinenxan A is facile to be transformed by microorganisms, the 10-acetyl group of which is an active group.