超声微泡作为基因或药物载体的研究进展

Recent advances in the applications of ultrasonic microbubbles as gene or drug vectors

摘要:
随着新型超声微泡造影剂的研究和应用, 超声微泡不仅能增强超声造影, 而且也能作为运送基因或药物的载体。在超声作用下, 含基因或药物的微泡能穿透血管内皮, 释放基因或药物, 达到靶向治疗目的。本文综述了超声微泡的生物学效应、制备和应用等方面的研究进展。

Abstract:
With the research and application of the new ultrasound microbubble contrast agents, ultrasonic microbubbles can not only help to image, but they can also be used as genes or drug carriers. The microbubbles as genes or drug carriers can pass across the endothelial cell barrier and release genes and drug under the action of ultrasound field, which achieve target treatment effect. Based on the relevant materials, the bioeffects, early successes with gene and drug delivery, and potential clinical applications are reviewed.