Abstract: The article determined the bioavailability and pharmacokinetic parameters of two kinds of nimodipine tablets produced by Tianjin Center Pharmaceutical Factory in 6 healthy volunteers using HPLC method. The commercially available conventional tablet A and the tablet formulation B were compared with the reference solution C in vivo. The pharmacokinetic parameters of nimodipine in vivo were estimated by using PKBP--N1 program on the basis of one compartment open model. After administration of 120 mg dose of B, the pharmacokinetic parameters were as follows: Tp=0.977 h, C_max=44.28ng/ml, ka=2.02 h^-1, t1/2=1.63 h, Vd=26. 25 L/ kg, AUC=130.56 ng·h^-1·ml^-1. The result imply that nimodipine is absorbed rapidly, distributed widely in the body, and also eliminated at a fairly rapid rate.The bioavailability of A and B relative to C was 16.01% and 82. 39% respectively. The new tablet formulation B is superior to tablet A.