盐酸丁螺环酮对动物口腔粘膜的渗透性及其机理

PERMEATION OF BUSPIRONE HYDROCHLORIDE ACROSS ANIMAL BUCCAL MUCOSA AND ITS MECHANISM

摘要: 目的　研究盐酸丁螺环酮对动物口腔粘膜的渗透性及渗透机理。方法　采用离体动物口腔粘膜的体外渗透试验方法,比较盐酸丁螺环酮对家兔、豚鼠、猪、羊和牛的口腔粘膜渗透性,考察药物浓度及溶液pH值的影响。结果　盐酸丁螺环酮对家兔口腔粘膜的渗透性最大,渗透速率随溶液pH值升高而增大,与药物浓度成正比。结论盐酸丁螺环酮通过口腔粘膜转运的方式为被动扩散,转运途径为穿过细胞途径

Abstract: AIM To study the permeation of busprione hydrochloride across animal buccal mucosa and its permeation mechanism. METHODS The in vitro penetration model was designed to investigate drug buccal mucosa permeability, and the influence factors (different animal oral mucosa, such as rabbit, guinea pig, pig, sheep and cow, drug concentrations and solution pH values) were measured. RESULTS The permeability of rabbit buccal mucosa for busprione hydrochloride was the largest. The permeation rate was increased with solution pH and directly to the drug concentration. CONCLUSION The transport way of busprione hydrochloride was passive diffusion and the transport channel was through cells.